Masafumi Kitakaze Selected Research

N- (1- ((2,4- diamino- 6- pteridinyl)methyl)- 3,4- dihydro - 2H- 1,4- benzothiazine- 7- carbonyl)- L- 2- aminoadipic acid

4/2004

Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts.

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Masafumi Kitakaze Research Topics

Disease

115	Heart Failure 05/2024 - 05/2002
31	Infarction (Infarctions) 12/2022 - 01/2002
28	Myocardial Infarction 12/2022 - 01/2002
22	Cardiomegaly (Heart Hypertrophy) 01/2022 - 01/2002
22	Ischemia 10/2021 - 01/2002
22	Reperfusion Injury 12/2017 - 01/2002
18	Hypertrophy 01/2024 - 09/2002
18	Myocardial Ischemia (Ischemic Heart Diseases) 05/2015 - 07/2002
17	Cardiovascular Diseases (Cardiovascular Disease) 06/2022 - 01/2003
15	Fibrosis (Cirrhosis) 09/2023 - 09/2004
15	Body Weight (Weight, Body) 01/2020 - 09/2002
14	Type 2 Diabetes Mellitus (MODY) 05/2024 - 05/2010
11	Hypertension (High Blood Pressure) 01/2023 - 07/2003
11	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2022 - 08/2003
11	Neoplasms (Cancer) 09/2017 - 03/2002
10	Left Ventricular Dysfunction 05/2024 - 07/2006
10	Hypoxia (Hypoxemia) 01/2022 - 01/2014
10	Heart Diseases (Heart Disease) 01/2022 - 08/2003
7	Atrial Fibrillation 05/2024 - 01/2012
7	Glucose Intolerance 01/2020 - 04/2006
7	Hypotension (Low Blood Pressure) 01/2020 - 10/2007
7	Diabetes Mellitus 01/2019 - 12/2003
6	Coronary Artery Disease (Coronary Atherosclerosis) 06/2022 - 05/2003
6	Coronary Occlusion 12/2004 - 01/2002
5	Cardiac Arrhythmias (Arrythmia) 12/2021 - 10/2005
5	Bradycardia 01/2019 - 02/2009
5	Atherosclerosis 06/2016 - 10/2006
4	Ventricular Remodeling 12/2023 - 04/2004
4	ST Elevation Myocardial Infarction 12/2022 - 10/2017
4	Cardiomyopathies (Cardiomyopathy) 10/2022 - 10/2007
4	Tachycardia (Tachyarrhythmias) 01/2022 - 01/2013
4	Chronic Renal Insufficiency 10/2020 - 11/2014
4	Atherosclerotic Plaque (Atheroma) 11/2018 - 07/2002
4	Stroke (Strokes) 10/2018 - 01/2011
4	Ventricular Fibrillation 06/2006 - 01/2002
3	Hyperemia 01/2023 - 07/2003
3	Insulin Resistance 01/2022 - 05/2009
3	Chronic Obstructive Pulmonary Disease (COPD) 01/2021 - 12/2006
3	Dyslipidemias (Dyslipidemia) 01/2020 - 01/2014

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2002
17	Brain Natriuretic Peptide (Natrecor)FDA Link 05/2024 - 12/2006
17	Adenosine (Adenocard)FDA LinkGeneric 09/2019 - 01/2002
16	dapagliflozinIBA 12/2023 - 01/2018
14	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 09/2005
13	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2017 - 01/2002
10	Sodium-Glucose Transporter 2 InhibitorsIBA 05/2024 - 01/2016
10	Adenosine Triphosphate (ATP)IBA 01/2020 - 09/2002
9	Angiotensin IIIBA 01/2020 - 10/2002
8	Biomarkers (Surrogate Marker)IBA 05/2024 - 08/2014
8	Phosphotransferases (Kinase)IBA 04/2019 - 03/2002
7	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2022 - 08/2003
7	AdiponectinIBA 10/2018 - 09/2005
7	5'-Nucleotidase (5' Nucleotidase)IBA 06/2008 - 09/2003
7	NG-Nitroarginine Methyl Ester (L-NAME)IBA 04/2006 - 01/2002
6	DiureticsIBA 01/2023 - 08/2014
6	Angiotensin Receptor AntagonistsIBA 01/2023 - 05/2003
6	Natriuretic PeptidesIBA 01/2023 - 06/2009
6	SodiumIBA 01/2023 - 01/2018
6	Mineralocorticoid Receptor AntagonistsIBA 01/2022 - 05/2003
6	Histamine (Histamine Dihydrochloride)FDA Link 01/2016 - 05/2006
6	Purinergic P1 Receptors (Adenosine Receptor)IBA 05/2015 - 01/2002
5	Eplerenone (Inspra)FDA LinkGeneric 01/2023 - 04/2006
5	Messenger RNA (mRNA)IBA 01/2023 - 03/2010
5	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2019 - 05/2013
5	Atrial Natriuretic Factor (ANF)IBA 08/2017 - 02/2004
5	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2010 - 02/2006
5	Nitric Oxide Synthase (NO Synthase)IBA 04/2006 - 01/2002
4	Sodium-Glucose Transport ProteinsIBA 05/2024 - 11/2019
4	CreatinineIBA 12/2023 - 05/2006
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2022 - 10/2002
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 03/2002
4	Small Interfering RNA (siRNA)IBA 11/2018 - 01/2014
4	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 11/2018 - 01/2002
4	Fibroblast Growth Factor-23IBA 10/2017 - 11/2014
4	Nicorandil (SG 75)IBA 10/2017 - 02/2004
4	Hormones (Hormone)IBA 02/2017 - 12/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 10/2006
4	landiololIBA 04/2014 - 01/2012
4	Amiodarone (Amiodarona)FDA LinkGeneric 04/2013 - 10/2005
4	Anti-Arrhythmia AgentsIBA 04/2013 - 01/2005
4	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 06/2010 - 07/2002
4	Protein Kinase CIBA 06/2008 - 07/2004
4	Raloxifene Hydrochloride (Evista)FDA Link 06/2004 - 01/2002
4	Selective Estrogen Receptor Modulators (SERM)IBA 06/2004 - 01/2002
3	candesartanIBA 01/2023 - 04/2006
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/2022 - 06/2010
3	CalciumIBA 01/2022 - 06/2010
3	N-propionylprocainamideIBA 01/2021 - 04/2014
3	Glycoside Hydrolase InhibitorsIBA 01/2020 - 04/2006
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2019 - 09/2002
3	olmesartanIBA 05/2018 - 07/2002
3	LipidsIBA 01/2018 - 07/2002
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2017 - 01/2010

Therapy/Procedure

46	Therapeutics 01/2023 - 01/2002
13	Percutaneous Coronary Intervention 12/2022 - 02/2004
5	Heart Transplantation (Grafting, Heart) 01/2022 - 03/2011
4	Patient Readmission 08/2018 - 12/2009
4	Glycemic Control 04/2016 - 04/2006
3	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2020 - 01/2012
3	Secondary Prevention 10/2018 - 05/2010